<!-- Anticipo a rentas incluido -->
            <ion-col size-xs="12" size-lg="4">
              <ion-item mode="md" class="item-form-group switch">
                <ion-label (click)="anticipoARentasIncluido.setValue(!anticipoARentasIncluido.value)">
                  Anticipo a rentas incluido
                </ion-label>
                <ion-toggle formControlName="AnticipoARentasIncluido" (ionChange)="handleAnticipoRentasIncluido($event)"></ion-toggle>
              </ion-item>
            </ion-col>

            <!-- Anticipo a rentas con IVA -->
            <ion-col size-xs="12" size-lg="4">
              <ion-item mode="md" class="item-form-group" [disabled]="anticipoARentasIncluido.value != true">
                <ion-label position="stacked">Anticipo a rentas con IVA</ion-label>
                <ion-input #inputAnticipoRentas type="text" inputmode="numeric" maxlength="13"
                  formControlName="AnticipoARentas" (ionChange)="handleCommissionsPercent($event)"
                  [brmasker]="{money: true, thousand: ',',  decimalCaracter: '.', decimal: '2'}">
                  <ion-icon name="logo-usd" slot="start" class="money-icon"></ion-icon>
                </ion-input>
              </ion-item>
              <div class="error-container" *ngIf="anticipoARentas.touched == true && anticipoARentas.errors">
                <div class="error-message" *ngIf="anticipoARentas.errors['required']">
                  <ion-icon name="information-circle-outline" aria-label="invalid input"></ion-icon>
                  <span>Campo obligatorio</span>
                </div>
              </div>
            </ion-col>

handleAnticipoRentasIncluido(event: CustomEvent) {

    const value = event.detail['checked'];

    if (value == true) {

      this.anticipoARentas.setValidators([Validators.required]);
      this.anticipoARentas.updateValueAndValidity();
      this.changeDetectorRef.detectChanges();
      this.anticipoARentas.markAsTouched();
      
    } else {
      
      this.anticipoARentas.clearValidators();
      this.anticipoARentas.updateValueAndValidity();
      this.changeDetectorRef.detectChanges();
    }
  }

Ionic:

   Ionic CLI                     : 5.1.0 (/usr/local/lib/node_modules/ionic)
   Ionic Framework               : @ionic/angular 4.7.4
   @angular-devkit/build-angular : 0.13.0
   @angular-devkit/schematics    : 7.2.3
   @angular/cli                  : 7.3.1
   @ionic/angular-toolkit        : 1.4.0

Cordova:

   Cordova CLI       : 9.0.0 (cordova-lib@9.0.1)
   Cordova Platforms : android 8.0.0, ios 5.0.1
   Cordova Plugins   : cordova-plugin-ionic-keyboard 2.1.3, cordova-plugin-ionic-webview 4.1.1, (and 13 other plugins)

Utility:

   cordova-res : not installed
   native-run  : 0.2.7 (update available: 0.2.8)

System:

   ios-deploy : 1.9.4
   ios-sim    : 8.0.1
   NodeJS     : v10.16.0 (/usr/local/bin/node)
   npm        : 6.9.0
   OS         : macOS Mojave
   Xcode      : Xcode 10.2.1 Build version 10E1001